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The neurocognitive effects of aluminum(Al)were studied in 35 hemodialysis patients.Highger Al levels were associated with a decline in visual memory.As Al levels increased,patients with lower vocabulary scores(a measure of premorbid intelligence)showed a decline in attention/ concentration,frontal lobe functions,and on several neurocognitive measures,while those with higher vocabulary scores revealed no Al-related decline.These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al.These data also indicate that Al is neurotoxic and,therefore,potential sources of environmental Al should be identified and eliminated. |
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